From the Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, TX; and University of Texas at Houston Health Science Center, Houston.
Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ib
, the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ib and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ib is different among whites and African Americans. The B allele (with 3 repeats) of GP Ib is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes. (Blood. 2004;103:963-965)
Identification of a Small Molecular Anti-HIV-1 Compound that Interferes with Formation of the Fusion -active gp41 Core
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The bidirectional cavopulmonary (Glenn) shunt without cardiopulmonary bypass: is it a safe option
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