From the Departments of Dermatology, Medicine, and Surgery, Brigham and Women's Hospital, Boston; the Harvard Skin Disease Research Center, Harvard Medical School, Boston; the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; and the Department of Oncology, School of Medicine, Georgetown University, Washington, DC.
For circulating lymphocytes to migrate to inflammatory sites, they must first adhere to the target tissue endothelium with sufficient strength to overcome the shear forces of blood flow. We previously reported that dermal papillary vessels in acute graft-versus-host disease (aGVHD) support shear-resistant lymphocyte adherence. We now identify the relevant adhesion molecule(s) directing this binding, showing that interactions between lymphocyte CD44 and hyaluronic acid (HA) expressed on dermal vessels in aGVHD alone confer this shear-resistant attachment. Native HA deposits on vascular endothelium support lymphocyte adherence, whereas HA immobilized on plastic does not. HA expressed at dermal endothelium in aGVHD is thus specialized to support lymphocyte adherence under flow conditions, and CD44-HA interactions may contribute to lymphocytotropism to skin in aGVHD.
A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group
A picture (in the microscope) is worth a thousand words
Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes
Added challenges to gene therapy—immune responses in the setting of myeloablation
Alphastatin a 24–amino acid fragment of human fibrinogen is a potent new inhibitor of activated endothelial cells in vitro and in vivo
Antibodies against lepirudin are polyspecific and recognize epitopes on bivalirudin
BAFF and related proteins: a new therapeutic target for B-cell malignancies
Clinical course of patients with WASP gene mutations
Complete response to donor lymphocyte infusion in multiple myeloma is associated with antibody responses to highly expressed antigens
Epidemiology of human parvovirus B19 in children with sickle cell disease