Adult human hematopoietic cells provide functional hemangioblast activity
From the Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL.
The murine adult hematopoietic stem cell is able to function as a hemangioblast, contributing both to blood reconstitution and to blood vessel repair in response to ischemic injury. We developed a novel mouse xenotransplantation model of retinal neovascularization to test human hematopoietic cell plasticity. Immunocompromised nonobese diabetic (NOD)/scid mice underwent myeloablative conditioning and transplantation with human CD34+ umbilical cord blood. After multilineage reconstitution was established, retinal ischemia was induced to promote neovascularization. Our results demonstrate human retinal neovascularization, thus revealing the functional hemangioblast activity of human hematopoietic cells.
热点推荐：
Administration of Hematopoietic Cytokines in the Subacute Phase After Cerebral Infarction Is Effective for Functional Recovery Facilitating Proliferation of Intrinsic Neural Stem/Progenitor Cells and
Simultaneous Reconstitution of Multiple Cytomegalovirus-Specific CD8+ Cell Populations with Divergent Functionality in Hematopoietic Stem-Cell Transplant Recipients
An In Vivo Analysis of Hematopoietic Stem Cell Potential
Distinct MYC thresholds in hematopoietic neoplasia
Hematopoietic stem cells, explicitly
A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation
The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
Administration of Hematopoietic Cytokines in the Subacute Phase After Cerebral Infarction Is Effective for Functional Recovery Facilitating Proliferation of Intrinsic Neural Stem/Progenitor Cells and
Simultaneous Reconstitution of Multiple Cytomegalovirus-Specific CD8+ Cell Populations with Divergent Functionality in Hematopoietic Stem-Cell Transplant Recipients
An In Vivo Analysis of Hematopoietic Stem Cell Potential
Distinct MYC thresholds in hematopoietic neoplasia
Hematopoietic stem cells, explicitly
A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation
The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
《血液学杂志》2004年1月第103卷第1期