From the Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA; and the Department of Medicine, University of Washington School of Medicine, Seattle.
Male recipients of transplants from female (F
M) hematopoietic stem cell donors represent a special group in whom donor T cells that are specific for recipient minor histocompatibility antigens encoded by Y-chromosome genes may contribute to a graft-versus-leukemia (GVL) effect and to graft-versus-host disease (GVHD). We examined the contribution of donor/patient sex to the risk for relapse and GVHD in 3238 patients who underwent HLA-identical sibling hematopoietic stem cell transplantation (HSCT) for hematopoietic malignancies at a single institution. Compared with other sex combinations, male recipients of female transplants had the lowest risk for relapse and the greatest odds for GVHD. Remarkably, after controlling for GVHD as a time-dependent covariate, FM HSCT still exhibited a lower risk for relapse than other sex combinations, demonstrating a selective GVL effect distinct from that contributed by GVHD. A reduction in relapse after FM HSCT was observed in patients with chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), and acute lymphoblastic leukemia (ALL). Taken together, these data suggest that minor H antigens encoded or regulated by genes on the Y chromosome contribute to a selective GVL effect against myeloid and lymphoid leukemias after FM HSCT.
Successful repair of chronic instability of anterior chest wall following right parasternal approach for closure of atrial septal defect in a young female
Female Mice Lacking Estrogen Receptor ; Display Prolonged Ventricular Repolarization and Reduced Ventricular Automaticity After Myocardial Infarction
Nature Usually Favors Females
Estimating Female-to-Male Infectivity of HIV-1 in Kenya: Potential Threats to Validity
Female-to-Male Infectivity of HIV-1 among Circumcised and Uncircumcised Kenyan Men
Female Genital-Tract HIV Load Correlates Inversely with Lactobacillus Species but Positively with Bacterial Vaginosis and Mycoplasma hominis
Inheritance of Susceptibility to Induced Escherichia coli Bladder and Kidney Infections in Female C3H/HeJ Mice
Cellular Human Immunodeficiency Virus (HIV)Protective Factors: A Comparison of HIV-Exposed Seronegative Female Sex Workers and Female Blood Donors in Abidjan, Côte d'Ivoire
Mutation of the Follicle-Stimulating Hormone Receptor Gene 5'-Untranslated Region Associated With Female Hypertension
Brachial Blood Pressure But Not Carotid Arterial Waveforms Predict Cardiovascular Events in Elderly Female Hypertensives